GRANTS FUNDED in 2006
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Recent Science Funding Provided
by the Hereditary Disease Foundation
Click here to begin your search
for research updates by HDF-funded scientists and others.
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over 12 million MEDLINE citations back to the mid-1960's and additional life
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Hereditary Disease Foundation grants, postdoctoral
fellowships and research contracts are helping identify
routes to the development of cures and treatments for
Huntington’s disease and other similar hereditary
disorders. With your support, the HDF’s Scientific
Advisory Board, comprised of world-renowned experts in
genetics, neurology, neuroscience, and therapy development,
has funded groundbreaking research. The following projects
were recently funded in 2006:
RESEARCH GRANTS
Jocelyne Caboche
Universite Pierre et Marie Curie, Paris, France.
Restoration of mitogen and stress-activated kinase as
a therapeutic approach in HD.
Yury Chernoff
Georgia Institute of Technology, Atlanta, GA.
Understanding the role of molecular chaperones and the
ubiquitin system in polyglutamine aggregation and toxicity.
Nico Dantuma
Karolinska Institute, Stockholm, Sweden.
How does mutant huntingtin disrupt normal protein degradation
and how can this be prevented?
Mate Dobrossy
Cardiff University, Cardiff, United Kingdom.
How does cell replacement therapy work in rodent models
of Huntington’s disease?
Angela Hodges
King’s College, London, United Kingdom.
How does Dictyostelium tolerate the burden of
polyglutamine-containing proteins?
Albert LaSpada
University of Washington, Seattle WA.
Elucidating the mechanism of energy disruption in Huntington’s
disease.
Eric Reits
University of Amsterdam, Amsterdam, The Netherlands.
Enhancing polyglutamine degradation as a treatment for
Huntington’s disease.
POSTDOCTORAL FELLOWSHIPS
Dena Cohen
Massachusetts Institute of Technology, Cambridge,
MA.
Mentor: Leonard Guarente
Modulation of SirT1, a longevity gene, as a treatment
for Huntington’s disease.
Xueyi Li
Massachusetts General Hospital, Boston, MA.
Mentor: Marian DiFiglia
Understanding and preventing the disruption of endocytosis
by mutant huntingtin protein.
RESEARCH CONTRACTS
Ron Kopito
Stanford University, Palo Alto, CA.
Cataloging disruptions of protein degradation machinery
in the brains of HD mice.
Alexander Osmand
University of Tennessee School of Medicine,
Knoxville, TN.
Understanding the early steps in polyglutamine aggregation
in the HD brains.
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