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2010 Funding Decisions
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for research updates by HDF-funded scientists and others.
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Hereditary Disease Foundation grants, postdoctoral fellowships and research contracts are helping to find treatments and cures for Huntington’s disease and other similar hereditary disorders. The HDF’s Scientific Advisory Board, comprised of world-renowned experts in genetics, neurology, neuroscience, and drug therapy development, meets three times each year to review and approve funding for groundbreaking research.
RESEARCH GRANT
Martin Duennwald
Boston Biomedical Research Institute
The immunoproteasome as a potential new therapeutic target in Huntington’s disease.
Jodi McBride
Oregon Health & Science University
Systemic delivery of RNA interference using AAV9: pushing the envelope for a global delivery strategy to treat Huntington’s disease.
POSTDOCTORAL FELLOWSHIPS
Rebecca Aron
J. David Gladstone Institute at University of California San Francisco
Mentor: Paul Muchowski
Validation of potential genetic modifiers of Huntington's disease in neuronal cells and mouse models.
Nicholas Franich
University of California, Los Angeles
Mentor: Marie-Francoise Chesselet
Direct comparison of CAG140 and CAG150 knock-in mouse models of Huntington’s disease: neuropathological and behavioral analysis.
Amanda Lumsden
Massachusetts General Hospital, Harvard University
Mentor: James Gusella
Investigating the normal function of huntingtin in Dictyostelium discoideum.
THE LESLIE GEHRY BRENNER PRIZE FOR INNOVATION IN SCIENCE
David Housman, Ph.D.
Massachusetts Institute of Technology
Discovered the Huntington’s disease gene, which helped launch the Human Genome Project.
Gillian P. Bates, M.Sc., Ph.D.
King’s College, UK
Generated the first mouse models of Huntington’s disease.
HEREDITARY DISEASE FOUNDATION SCHOLARS
The following individuals’ applications were approved by the Scientific Advisory Board of the Hereditary Disease Foundation, but received their funding elsewhere. To acknowledge this approval by the Scientific Advisory Board, we are designating them as Hereditary Disease Foundation Scholars:
Joanna Dragich
Columbia University
Mentor: Ai Yamamoto
The role of Autophagy-linked FYVE domain protein (Alfy) in disease reversal in a mouse model of HD.
Clare Gladding
University of British Columbia
Mentor: Lynn Raymond
Investigating altered NMDA receptor signaling in a transgenic mouse model of Huntington disease.
Shilpa Rao
University of California, Los Angeles
Mentor: Michael Levine
Alterations in GABAergic microcircuits in the striatum in mouse models of Huntington’s disease.
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