Cure Found for Huntington
Disease in Mice Offers Hope for Treatment in Humans
- VANCOUVER, B.C. – June 16, 2006
Researchers at the Child and Family
Research Institute's Centre for Molecular Medicine and Therapeutics
(CMMT) have provided ground-breaking evidence for a cure for
Huntington disease in a mouse offering hope that this disease can be
relieved in humans.
Published today in Cell journal, Dr.
Michael Hayden and colleagues discovered that by preventing the
cleavage of the mutant huntingtin protein responsible for Huntington
disease (HD) in a mouse model, the degenerative symptoms underlying
the illness do not appear and the mouse displays normal brain
function. This is the first time that a cure for HD in mice has been
successfully achieved. [click
here for full press release]
Research holds promise
for Huntington's treatment
- Researchers at MIT and Harvard Medical School have identified a compound that interferes with
the pathogenic effects of Huntington's disease, a discovery that could lead to
development of a new treatment for the disease...
FROM
http://web.mit.edu/newsoffice/2006/huntington.html
[ Read Ruth
Bodner's article here (PDF format) ]
Neural Transplants Provide
Persistent Benefit In Patients With Huntington’s Disease -
Neuronal transplantation in Huntington’s disease provides a period of
improvement and stability of several years, according to an article published
Online today (Monday February 27, 2006) by The Lancet Neurology.
Effect of fetal neural
transplants in patients with Huntington’s disease 6 years after surgery: a
long-term follow-up study
- Article:
Anne-Catherine Bachoud-Lévi, Véronique Gaura, Pierre Brugières, Jean-Pascal
Lefaucheur, Marie-Françoise Boissé, Patrick Maison, Sophie Baudic, Maria-Joao
Ribeiro, Catherine Bourdet, Philippe Remy, Pierre Cesaro, Philippe Hantraye,
Marc Peschanski
Drug
Found To Reduce Involuntary Movements In Huntington's Disease -
Tetrabenazine Update:
Study Finds Drug May Cut Down Involuntary Movements In Huntington's Disease Patients By 25 Percent
- [.pdf]
Drug aimed at Huntington's eases chorea, the disease's hallmark feature - [ .pdf ]
Study Published in Neurology Shows Tetrabenazine Significantly Improves Debilitating Movement Disorder Caused by Huntington's Disease
- [ .pdf ]
Prestwick drug looks good for Huntington's
- [.pdf]
Venezuelan
Kindreds Reveal Genetic and Environmental Factors Influence Onset of
Huntington’s Disease :
New York, New York – March 2, 2004– The age at which Huntington’s disease starts is not solely determined by the Huntington’s disease gene, as previously believed, but is strongly influenced by genetic and environmental factors, according to new findings from a team led by Columbia University Medical Center researcher and president of the Hereditary Disease Foundation Dr. Nancy Wexler.
Gene
therapy may switch off Huntington's - March 13, 2003 -
HD
Lighthouse - Using gene therapy to switch off genes instead of adding new
ones could slow down or prevent the fatal brain disorder Huntington's disease.
The method, which exploits a mechanism called RNA interference, might also help
treat a wide range of other inherited diseases.
Major Advances in Huntington's Disease
Research Expected From Powerful Technology to Study Protein Structure - December 04, 2002 - The Hereditary Disease Foundation
(HDF) and Structural GenomiX, Inc. (SGX) today announced a collaboration agreement to investigate the structure of
huntingtin, the protein responsible for Huntington’s disease.
Huntington's Disease Study Offers New Hope - November 20, 2001 - First hints that something can be done to defeat the inherited brain disorder called Huntington's disease are coming from experiments in fruit flies.
Hereditary Disease Foundation Scientists Find
Possible Treatment For Huntington's Disease - October 22, 2001 - UC Irvine Researchers Show for the First Time How Existing Therapies
May Arrest and Prevent Nerve Damage in Incurable Genetic Brain Disorder.
Therapeutic Opportunities in Polyglutamine Disease Nature Medicine. April 2001. Research towards a therapeutic drug in many polyglutamine diseases with a focus on Huntington's Disease. Drs. Bob Hughes and Jim Olson are two of the many HD researchers who have been instrumental in the steady progress towards therapeutic interventions.
Treatment for Huntington's Disease Shows Promise LA Times. November 30, 2000. French researchers find that fetal brain cell transplants reversed the disease in three of five patients over a two year period. Also visit
The Lancet, a fetal cell research website.
Green light to a cure Jellyfish's eerie glow may be the key to unlocking Huntington's Disease Newsday. October 3, 2000. The glow, they hope, will lead toward a cure for Huntington's disease
Jellyfish May Help Scientists Decipher Genetic Mysteries Wall Street Journal. September 12, 2000. Helps scientists tackle one of the most daunting challenges facing drug-hunting researchers: quickly turning the spate of new gene discoveries into innovative medicines.
Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease . Ai
Yamamoto, Jose J. Lucas, & Rene Hen. Cell, March 31, 2000. FEATURING HDF SUPPORTED
RESEARCH.
Reversing Neurodegeneration: A Promise Unfolds . Harry T. Orr & Huda Y. Zogbi. Cell, March 31, 2000.
Delaying the Onset of Huntington's in Mice . Anto van Dellen et. all. Nature, April 13, 2000.
Disease's Surprise Data could lead to Huntington's treatment . FEATURING HDF SUPPORTED RESEARCH. Newsday Article, 5/18/2000.
Largest Huntington's Drug Study Ever
On the Trail of a Killer, They Discovered Hope . Los Angeles Times article from Sunday, November 14, 1999.
Crucial Turning Point in the Quest for a Cure for Huntington's Disease
-
In the August 8 issue of Cell, two scientific papers report a crucial
breakthrough in the quest for a cure for Huntington's disease. Possibly the biggest news for someone at risk for Huntington's disease.
August 7, 1997.
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