Additionally, here are two useful articles about HD and sleep written by Dr. Morton: 1) HD and Sleep and 2) Simple rules for a good night's sleep in Huntington's disease.

About the Speakers

A. Jennifer Morton, PhD, ScD, FRSB
Professor of Neurobiology
University of Cambridge
Professorial Fellow
Director of Studies in Medicine and Veterinary Medicine
Newnham College, Cambridge

Dr. A. Jennifer Morton has been working on Huntington’s disease ever since she set up her laboratory at the University of Cambridge in 1991. She is interested in understanding the relationship between neurodegeneration and the neurological symptoms in HD. She is particularly interested in sleep, circadian rhythms and cognitive decline in HD. With funding from the Hereditary Disease Foundation, The Wellcome Trust, and CHDI Foundation, she has characterized the behavioral profile of a number of mouse models of HD.

For the past 10 years, Dr. Morton has also been working with HD sheep. She believes that, although it is an unconventional model, there is much to be gained from understanding the behavioral pathology in this large-brained diurnal model of HD. Her lab’s goal is to identify quantifiable measures of behavior that can be used to test the efficacy of novel therapies for HD.

H. Diana Rosas, MD
Associate Professor, Departments of Neurology and Radiology
Director, Center for Neuro-imaging of Aging and Neurodegenerative Disease
Massachusetts General Hospital, Harvard Medical School

Dr. H. Diana Rosas focuses primarily on the development of biomarkers for use in the study of neurodegenerative diseases to better characterize progression, to better understand genotype/phenotype correlations, and to apply novel neuro-imaging approaches in clinical trials with the overall aim of making the trials more efficient.

Dr. Rosas and her team have begun to develop models that may explain clinically heterogeneous phenotypes and variability in disease progression. They plan to expand their efforts to include several different types of imaging approaches that promise more precise measurements and may provide novel and important information on the neural underpinnings of HD and their clinical consequences.

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